Aminoglycoside toxicity free download as powerpoint presentation. Aminoglycoside toxicity renal function antibiotics. To learn about side effects and potential toxicity of aminoglycosides, lets visit jack, a patient in the hospital who is being treated with an aminoglycoside antibiotic. Aminoglycosides are commonly prescribed antibiotics with deleterious side effects to the inner ear. A single dose of aminoglycoside results in significantly lower renal cortical tissue concentration compared to the same total dose administered through a continuous infusion or in divided doses. Daily versus thriceweekly dosing for treatment of mycobacterial diseases charles a. Aminoglycoside dosing and monitoring guidelines for adult patients at stony brook university hospital algorithm for initial aminoglycoside dosing egfr is normalized to bsa 1. Aminoglycoside toxicity, therefore, is a significant side effect to the aminoglycoside drugs.
A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. In this forum, i will summarize the renal handling of the aminoglycosides, the pathogenetic mechanisms of nephro toxicity, and the clinical aspects of aminoglycoside induced acute renal failure. Once daily peaks are 23 times greater thanmultipledosing. Timing of blood levels is important in interpreting results. In stable patients, may consider monitoring 18hour levels, with goals as in appendix i.
Aminoglycosides cause toxicity of the vestibular balance or cochlear hearing systems of the inner ear in up to 10% of patients receiving these drugs intravenously. Daily versus thriceweekly dosing for treatment of mycobacterial diseases. Aminoglycoside antibiotics free download as powerpoint presentation. Draw blood for peak troughlevelsshouldbedrawnjustbeforenextdose. Route onset peak duration gentamicin jentamyesin im. Mechanisms of aminoglycoside ototoxicity and targets of.
In addition, antibiotics in this group can also make people with muscular conditions like myasthenia gravis worse, and can slow recovery from anesthetics like succinylcholine or curare. Aminoglycosides are a class of antibiotics used to treat serious infections caused by bacteria that either multiply very quickly or are difficult to treat. Aminoglycosideinduced ototoxicity can profoundly affect quality of life. Aminoglycoside dosing and monitoring guidelines for adult. Frequently permanent, toxicity can result in failure to return to work and diminished quality of life. After almost seven decades in clinical use, aminoglycoside antibiotics still remain indispensible drugs for acute infections and specific indications such as tuberculosis or the containment of pseudomonas bacteria in patients with cystic fibrosis. Stanford health care aminoglycoside dosing guideline. Aminoglycosides warnings, precautions, side effects. Due to their popular application as a result of their potent antimicrobial activities, many efforts have been undertaken to prevent aminoglycoside ototoxicity.
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